Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22736025 | 0.85 | NPSR1 (0.38) | SLC18A3EGLN1RIPK2RET | |
| SCHEMBL29480648 | 0.76 | NPSR1 (0.35) | SLC18A3RIPK2 | |
| SCHEMBL22736529 | 0.73 | PIK3CD (0.36) | EGLN1RIPK2KDM4EGRM4RET | |
| SCHEMBL22736535 | 0.69 | EGLN1 (0.42) | EGLN1GRM4 | |
| SCHEMBL29480770 | 0.69 | EGLN1 (0.42) | EGLN1GRM4 | |
| SCHEMBL29480674 | 0.69 | JAK2 (0.41) | — | |
| SCHEMBL29480769 | 0.68 | MAP3K7 (0.37) | GRM4 | |
| SCHEMBL22735955 | 0.68 | MAP3K7 (0.37) | GRM4 | |
| SCHEMBL29480654 | 0.67 | GRM4 (0.35) | KDM4EGRM4 | |
| SCHEMBL22736355 | 0.67 | MELK (0.33) | KDM4EGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |