Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480648 | 0.88 | NPSR1 (0.35) | NPSR1JAK2DYRK3WNT1CLK1 | |
| SCHEMBL22736247 | 0.85 | SLC18A3 (0.35) | SLC18A3RIPK2RETEGLN1 | |
| SCHEMBL29480674 | 0.83 | JAK2 (0.41) | NPSR1JAK2DYRK3WNT1CLK1 | |
| SCHEMBL22736529 | 0.74 | PIK3CD (0.36) | JAK2JAK1RIPK2RETEGLN1 | |
| SCHEMBL29567290 | 0.72 | EGLN1 (0.38) | EGLN1KCNH2 | |
| SCHEMBL22736535 | 0.70 | EGLN1 (0.42) | METEGLN1 | |
| SCHEMBL29480770 | 0.70 | EGLN1 (0.42) | METEGLN1 | |
| SCHEMBL22716934 | 0.69 | NPSR1 (0.53) | NPSR1SLC18A3CYP11B2MAPTLMNA | |
| SCHEMBL29480699 | 0.69 | NPSR1 (0.53) | NPSR1SLC18A3CYP11B2MAPTLMNA | |
| SCHEMBL22735955 | 0.68 | MAP3K7 (0.37) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |