Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 11/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TEX264 | Q9Y6I9 | 1/20 | 0.50 |
| ▸ | IDH2 | P48735 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908990 | 0.83 | SMN1; SMN2 (0.58) | GAAMAPTALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL30568813 | 0.78 | USP2 (0.83) | MAPTSMN1; SMN2USP2KMT2AHTT | |
| SCHEMBL13942796 | 0.78 | SMN1; SMN2 (0.49) | GAAMAPTALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL8909067 | 0.77 | CTSL (0.52) | GAAMAPTALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL3758998 | 0.77 | USP2 (0.87) | MAPTSMN1; SMN2USP2KMT2AMEN1 | |
| SCHEMBL28449253 | 0.76 | USP2 (0.78) | MAPTSMN1; SMN2USP2KMT2AMEN1 | |
| SCHEMBL32669200 | 0.75 | GAA (0.59) | GAAHPGDMAPTALDH1A1KMT2A | |
| SCHEMBL22737353 | 0.74 | MAPT (0.68) | GAAHPGDMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL32669325 | 0.74 | GAA (0.65) | GAAHPGDMAPTALDH1A1KMT2A | |
| SCHEMBL15890518 | 0.74 | MTOR (0.65) | GAAHPGDMAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200375996-A1 | METHOD OF TREATING NEURODEGENERATIVE DISORDERS BY RESCUING ALPHA-SYNUCLEIN TOXICITY | D.E. SHAW RESEARCH, LLC (US) | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200375996-A1 | METHOD OF TREATING NEURODEGENERATIVE DISORDERS BY RESCUING ALPHA-SYNUCLEIN TOXICITY | SNCA, PARK7, NEDD4 | GAA 104/4885HPGD 3896/4885MAPT 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.