SCHEMBL2274099

SCHEMBL2274099

C=C[Si](CCCC)(c1ccccc1)N(CC)CC

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.33
KCNH2 Q12809 3/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2267186 0.85 MEN1 (0.32) TSHRMEN1KMT2ANPSR1
SCHEMBL2100941 0.74 TSHR (0.37) TSHRKCNH2MEN1KMT2ANPSR1
SCHEMBL2269308 0.74 TSHR (0.37) TSHRKCNH2MEN1KMT2ANPSR1
SCHEMBL27943213 0.73 NR1H2 (0.33) TSHRMEN1KMT2ANPSR1
SCHEMBL2269336 0.72 MAPT (0.31) TSHRNPSR1
SCHEMBL2276682 0.72 MAPT (0.31) TSHRNPSR1
SCHEMBL15302895 0.71 NR1H2 (0.32) TSHRMEN1KMT2ANPSR1
SCHEMBL2291148 0.71 PCSK9 (0.34) TSHR
SCHEMBL2272329 0.71 THRA (0.33) TSHRMEN1KMT2A
SCHEMBL2102086 0.71 TSHR (0.35) TSHRKCNH2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed