Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 17/20 | 0.71 |
| ▸ | NOS3 | P29474 | 15/20 | 0.71 |
| ▸ | NOS2 | P35228 | 15/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22742306 | 0.86 | NOS1 (0.88) | NOS1NOS3NOS2 | |
| SCHEMBL6645211 | 0.83 | NOS1 (1.00) | NOS1NOS3NOS2 | |
| SCHEMBL22743544 | 0.81 | NOS1 (0.53) | NOS1NOS3NOS2 | |
| SCHEMBL13826592 | 0.72 | NOS3 (0.41) | NOS1NOS3NOS2 | |
| SCHEMBL6643393 | 0.70 | NOS1 (1.00) | NOS1NOS3NOS2 | |
| SCHEMBL22717048 | 0.69 | NOS1 (0.40) | NOS1NOS3NOS2 | |
| SCHEMBL14100576 | 0.69 | NOS3 (0.62) | NOS1NOS3NOS2HTR2CCHRNB2 | |
| SCHEMBL22716960 | 0.69 | NOS1 (0.40) | NOS1NOS3NOS2 | |
| SCHEMBL22742869 | 0.69 | NOS3 (0.50) | NOS1NOS3NOS2HTR2AHTR2C | |
| SCHEMBL20708296 | 0.68 | NOS3 (0.53) | NOS1NOS3NOS2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243178-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2020-12-03 | — | — | WO | disclosed |