SCHEMBL8468947

SCHEMBL8468947

CCOC[SiH](COCC)c1ccccc1C

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.35
ACHE P22303 1/20 0.35
ESR1 P03372 1/20 0.33
TDP1 Q9NUW8 1/20 0.32
GAA P10253 1/20 0.30
PIN1 Q13526 1/20 0.30
KDM4E B2RXH2 1/20 0.30
CYP1A2 P05177 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274332 0.79 ACHE (0.38) TSHRACHEESR1KDM4ECYP1A2
SCHEMBL30843826 0.78 SCN4A (0.33) TSHRACHEESR1TDP1KDM4E
SCHEMBL28728735 0.76 TSHR (0.43) TSHRACHEESR1TDP1GAA
O-Xylene SCHEMBL9688145 0.73 TSHR (0.59) TSHRACHEESR1TDP1GAA
SCHEMBL103756 0.71 TSHR (0.38) TSHRACHEESR1TDP1GAA
SCHEMBL27614186 0.71 TSHR (0.38) TSHRACHEESR1TDP1GAA
SCHEMBL12119414 0.71 TSHR (0.38) TSHRACHEESR1TDP1GAA
O-Xylene SCHEMBL27742416 0.67 TSHR (0.43) TSHRACHEESR1KDM4ECYP1A2
O-Xylene SCHEMBL28327087 0.66 TSHR (0.48) TSHRACHETDP1GAAKDM4E
SCHEMBL4778077 0.65 TSHR (0.36) TSHRACHEESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5877265-A Solid titanium catalyst component for olefin polymerization, process for preparing the same, catalyst for olefin polymerization and process for olefin polymerization MITSUI CHEIMCALS, INC. (JP) 1999-03-02 US disclosed