SCHEMBL227447

SCHEMBL227447

Cc1cccc([N+](=O)[O-])c1Br

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.64
SMN1; SMN2 Q16637 1/20 0.64
HSD17B10 Q99714 1/20 0.63
TDP1 Q9NUW8 5/20 0.59
L3MBTL1 Q9Y468 2/20 0.55
ALDH1A1 P00352 5/20 0.54
CYP1A2 P05177 2/20 0.50
GPR35 Q9HC97 2/20 0.48
MAPT P10636 2/20 0.43
MAPK1 P28482 2/20 0.43
NPC1 O15118 1/20 0.43
LMNA P02545 1/20 0.43
S100A4 P26447 1/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
ALOX15 P16050 1/20 0.42
NOS1 P29475 1/20 0.42
CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3126302 0.84 GPR35 (0.65) TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1
Selenium SCHEMBL11463644 0.82 GPR35 (0.62) TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1
SCHEMBL8330662 0.81 CYP1A2 (0.52) TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1
SCHEMBL700469 0.78 TSHR (1.00) TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1
SCHEMBL1176389 0.78 TDP1 (0.54) TSHRSMN1; SMN2HSD17B10TDP1ALDH1A1
SCHEMBL29431835 0.78 TDP1 (0.54) TSHRSMN1; SMN2HSD17B10TDP1ALDH1A1
SCHEMBL6051840 0.78 TSHR (0.69) TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1
SCHEMBL29538967 0.78 TSHR (1.00) TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1
SCHEMBL29431836 0.78 TDP1 (0.54) TSHRSMN1; SMN2HSD17B10TDP1ALDH1A1
SCHEMBL26502971 0.78 S100A4 (0.55) TSHRSMN1; SMN2HSD17B10TDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 266 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113214041-A Novel method for preparing 3-iodine-2 bromotoluene 河北唯达生物医药产业技术研究有限公司 2021-08-06 CN claimed
CN-106450499-A Lead-acid storage battery electrolyte and preparation method thereof 陈申申 2017-02-22 CN claimed
CN-106084714-A A kind of agricultural mulching and preparation method thereof 吉林省农业科学院 2016-11-09 CN claimed
CN-105017569-A Degradable composite tourist commodity packaging film and preparation method thereof JILIN TECHNOLOGY COLLEGE OF ELECTRONIC INFORMATION 2015-11-04 CN claimed
US-12448368-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2025-10-21 US disclosed
US-20250122176-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES INC (US) 2025-04-17 US disclosed
US-20250092021-A9 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2025-03-20 US disclosed
US-20240390387-A1 SULFONAMIDE OR SULFINAMIDE COMPOUND HAVING EFFECT OF INDUCING BRD4 PROTEIN DEGRADATION AND PHARMACEUTICAL USE THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2024-11-28 US disclosed
US-20240368123-A1 AROMATIC RING-CONTAINING BIOLOGICAL ANTAGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) 2024-11-07 US disclosed
US-12102641-B2 Sulfonamide or sulfinamide compound having effect of inducing BRD4 protein degradation and pharmaceutical use thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2024-10-01 US disclosed
CN-118324684-A Antitumor compound and pharmaceutical composition and application thereof 上海中医药大学 2024-07-12 CN disclosed
EP-4393920-A1 AROMATIC RING-CONTAINING BIOLOGICAL ANTAGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF Shanghai Hansoh Biomedical Co., Ltd. (CN) 2024-07-03 EP disclosed
US-4536591-A Insecticidal [1,1'-biphenyl]-3-ylmethyl esters FMC CORPORATION (US) 1985-08-20 US disclosed
US-4402973-A Insecticidal (1,1'-biphenyl)-3-ylmethyl esters FMC CORPORATION (US) 1983-09-06 US disclosed
EP-0062659-A4 3-(PYRROL-1-YL)PHENYLMETHYL ESTERS AND INTERMEDIATES. FMC CORP (US) 1983-01-14 EP disclosed
EP-0062659-A1 3-(PYRROL-1-YL)PHENYLMETHYL ESTERS AND INTERMEDIATES FMC Corporation (US) 1982-10-20 EP disclosed
US-4339457-A OF CYCLOPROPANECARBOXYLIC ACIDS, INSECTICIDES, MITICIDES FMC CORPORATION (US) 1982-07-13 US disclosed
US-4329518-A INSECTICIDES, ACARICIDES, MITICIDES FMC CORPORATION (US) 1982-05-11 US disclosed
WO-1982001368-A1 3-(PYRROL-1-YL)PHENYLMETHYL ESTERS AND INTERMEDIATES FMC CORP (US) 1982-04-29 WO disclosed
EP-0049977-A1 Insecticidal (1,1'-biphenyl)-3-ylmethyl esters, their production and use and compositions containing them FMC Corporation (US) 1982-04-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250122176-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 TSHR 509/4885SMN1; SMN2 1436/4885HSD17B10 150/4885
US-20250092021-A9 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 TSHR 509/4885SMN1; SMN2 1436/4885HSD17B10 150/4885
US-12448368-B2 Indole compounds as androgen receptor modulators AR, FSHR, ADRB3 TSHR 548/4885SMN1; SMN2 1509/4885HSD17B10 186/4885
US-12102641-B2 Sulfonamide or sulfinamide compound having effect of inducing BRD4 protein degradation and pharmaceutical use thereof BRD4, BRD1, BRD2 TSHR 3040/4885SMN1; SMN2 2513/4885HSD17B10 3412/4885
US-20240390387-A1 SULFONAMIDE OR SULFINAMIDE COMPOUND HAVING EFFECT OF INDUCING BRD4 PROTEIN DEGRADATION AND PHARMACEUTICAL USE THEREOF BRD4, BRD1, BRD2 TSHR 3040/4885SMN1; SMN2 2513/4885HSD17B10 3412/4885
US-20240368123-A1 AROMATIC RING-CONTAINING BIOLOGICAL ANTAGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF REN, BDKRB2, BDKRB1 TSHR 1309/4885SMN1; SMN2 4885/4885HSD17B10 1613/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.