Sugi Predict

Sugi Predict / Compounds / SCHEMBL22747342

SCHEMBL22747342

SCHEMBL22747342

CC(C)c1cn(Cc2ccccc2F)cn1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM5B Q9UGL1 2/20 0.47
▸ KDM4A O75164 1/20 0.47
▸ KDM5A P29375 1/20 0.47
▸ KDM4C Q9H3R0 1/20 0.47
▸ ALDH1A1 P00352 4/20 0.40
▸ L3MBTL1 Q9Y468 2/20 0.40
▸ MAPT P10636 2/20 0.40
▸ PKM P14618 1/20 0.40
▸ PDE5A O76074 1/20 0.39
▸ PDE4A P27815 1/20 0.39
▸ PDE1A P54750 1/20 0.39
▸ PDE1B Q01064 1/20 0.39
▸ PDE4B Q07343 1/20 0.39
▸ PDE4C Q08493 1/20 0.39
▸ PDE4D Q08499 1/20 0.39
▸ PDE3B Q13370 1/20 0.39
▸ PDE1C Q14123 1/20 0.39
▸ PDE3A Q14432 1/20 0.39
▸ POLB P06746 1/20 0.38
▸ MEN1 O00255 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19220556 0.82 KDM5B (0.43) KDM5BKDM4AKDM5AKDM4CALDH1A1
SCHEMBL19220558 0.80 PHF8 (0.38) KDM5BKDM5AKDM4C
SCHEMBL22718313 0.80 KDM5B (0.50) KDM5BKDM4AKDM5AKDM4CALDH1A1
SCHEMBL31331998 0.80 KDM5B (0.50) KDM5BKDM4AKDM5AKDM4CALDH1A1
SCHEMBL26276579 0.80 KDM5B (0.50) KDM5BKDM4AKDM5AKDM4CALDH1A1
SCHEMBL24845157 0.79 KDM5B (0.52) KDM5BKDM4AKDM5AKDM4CALDH1A1
SCHEMBL22747343 0.78 CPB2 (0.49) KDM5BKDM5AKDM4CMAPTPOLB
SCHEMBL22747288 0.77 KDM5B (0.48) KDM5BKDM4AKDM5AKDM4CALDH1A1
SCHEMBL2968205 0.76 ALDH1A1 (0.51) KDM5BKDM4AKDM5AKDM4CALDH1A1
SCHEMBL24845233 0.76 KDM5B (0.50) KDM5BKDM4AKDM5AKDM4CALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024092116-A1 COMBINATION OF TEAD INHIBITORS AND EGFR INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2024-05-02 — — WO disclosed
US-11760728-B2 Tead inhibitors and uses thereof Ikena Oncology, Inc. (US) 2023-09-19 — — US disclosed
US-11760728-B2 Tead inhibitors and uses thereof Ikena Oncology, Inc. (US) 2023-09-19 — — US disclosed
WO-2022120355-A1 TEAD DEGRADERS AND USES THEREOF Ikena Oncology, Inc. (US) 2022-06-09 — — WO disclosed
US-11274082-B2 Tead inhibitors and uses thereof Ikena Oncology, Inc. (US) 2022-03-15 — — US disclosed
US-20200407327-A1 TEAD INHIBITORS AND USES THEREOF THE EHE FOUNDATION 2020-12-31 — — US disclosed
WO-2020243415-A2 TEAD INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2020-12-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11274082-B2 Tead inhibitors and uses thereof TEAD2, TEAD3, TEAD4 KDM5B 931/4885KDM4A 1203/4885KDM5A 1116/4885
US-11760728-B2 Tead inhibitors and uses thereof TEAD2, TEAD3, TEAD4 KDM5B 931/4885KDM4A 1203/4885KDM5A 1116/4885
US-20200407327-A1 TEAD INHIBITORS AND USES THEREOF TEAD2, TEAD3, TEAD4 KDM5B 931/4885KDM4A 1203/4885KDM5A 1116/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.