Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28697181 | 0.89 | LMNA (0.46) | SMN1; SMN2LMNAHTTNPC1NR2F2 | |
| SCHEMBL28702756 | 0.84 | LMNA (0.48) | SMN1; SMN2LMNAHTTNPC1NR2F2 | |
| SCHEMBL28932211 | 0.83 | LMNA (0.48) | SMN1; SMN2LMNAHTTNPC1NR2F2 | |
| SCHEMBL28682374 | 0.82 | GPR119 (0.45) | SMN1; SMN2LMNAHTTNPC1NR2F2 | |
| SCHEMBL30768232 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAHTTNPC1NR2F2 | |
| SCHEMBL28699335 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAHTTNPC1NR2F2 | |
| SCHEMBL28677826 | 0.76 | MAPT (0.48) | SMN1; SMN2LMNAHTTMAPTALDH1A1 | |
| SCHEMBL30776728 | 0.72 | LMNA (0.49) | SMN1; SMN2LMNAHTTNPC1NR2F2 | |
| SCHEMBL20159003 | 0.72 | MAPT (0.59) | SMN1; SMN2LMNAHTTMAPTALDH1A1 | |
| SCHEMBL3050675 | 0.71 | LMNA (0.46) | SMN1; SMN2LMNAHTTNPC1NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113874354-A | Pyridone derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-12-31 | — | — | CN | disclosed |
| WO-2020244539-A1 | PYRIDONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 江苏恒瑞医药股份有限公司 | 2020-12-10 | — | — | WO | disclosed |