Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22748263 | 0.90 | MAPK8 (0.40) | MAPTALDH1A1GAATP53THRB | |
| SCHEMBL22760095 | 0.89 | MAPT (0.48) | MAPTALDH1A1GAATP53THRB | |
| SCHEMBL22760117 | 0.88 | FOLH1 (0.36) | MAPTALDH1A1GAATP53THRB | |
| SCHEMBL22760170 | 0.86 | ALDH1A1 (0.36) | MAPTALDH1A1GAATP53THRB | |
| SCHEMBL22760451 | 0.85 | LMNA (0.34) | MAPTALDH1A1GAATP53THRB | |
| SCHEMBL22760173 | 0.83 | ALDH1A1 (0.53) | MAPTALDH1A1GAATP53THRB | |
| SCHEMBL22760171 | 0.81 | MAPT (0.51) | MAPTALDH1A1GAATP53THRB | |
| SCHEMBL22748351 | 0.81 | MAPT (0.48) | MAPTALDH1A1GAATP53THRB | |
| SCHEMBL22760172 | 0.80 | MAPT (0.47) | MAPTALDH1A1GAATP53THRB | |
| SCHEMBL22747829 | 0.76 | FOLH1 (0.35) | MAPTALDH1A1GAATP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |