Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | PDE7A | Q13946 | 7/20 | 0.49 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29133541 | 0.76 | PDE7A (0.51) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL19175613 | 0.73 | PDK1 (0.61) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL29485992 | 0.73 | LMNA (0.56) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL22748314 | 0.73 | LMNA (0.56) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL10387432 | 0.70 | PDE7A (0.71) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL11442169 | 0.70 | PDE7A (0.50) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL17068903 | 0.69 | PDE7A (0.58) | MAPTALDH1A1LMNAMAPK1PDE7A | |
| SCHEMBL31090820 | 0.69 | PDE7A (0.73) | MAPTALDH1A1LMNASMN1; SMN2PDE7A | |
| SCHEMBL2020498 | 0.69 | PDE7A (0.73) | MAPTALDH1A1LMNASMN1; SMN2PDE7A | |
| SCHEMBL8091743 | 0.69 | HPGD (0.60) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976185-A1 | HECT E3 LIGASE INHIBITORS AND USES THEREOF | IFOM - Fondazione Istituto FIRC di Oncologia Molecolare (IT) | 2022-04-06 | — | — | EP | disclosed |
| WO-2020245213-A1 | HECT E3 LIGASE INHIBITORS AND USES THEREOF | IFOM - FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (IT) | 2020-12-10 | — | — | WO | disclosed |