Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 10/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.62 |
| ▸ | SIRT3 | Q9NTG7 | 8/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CPB1 | P15086 | 1/20 | 0.57 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.57 |
| ▸ | TLR2 | O60603 | 1/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.48 |
| ▸ | CHRNG | P07510 | 1/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.48 |
| ▸ | CHRND | Q07001 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16217772 | 1.00 | SIRT2 (0.62) | SIRT2SIRT1SIRT3MEN1ALDH1A1 | |
| SCHEMBL18972974 | 0.95 | SIRT2 (0.70) | SIRT2SIRT1SIRT3MEN1ALDH1A1 | |
| SCHEMBL16217828 | 0.92 | SIRT2 (0.55) | SIRT2SIRT1SIRT3MEN1ALDH1A1 | |
| SCHEMBL19871881 | 0.92 | SIRT2 (0.55) | SIRT2SIRT1SIRT3MEN1ALDH1A1 | |
| SCHEMBL19062407 | 0.91 | MEN1 (0.71) | SIRT2SIRT1SIRT3MEN1ALDH1A1 | |
| SCHEMBL18791194 | 0.90 | CPB1 (0.57) | SIRT2SIRT1SIRT3MEN1ALDH1A1 | |
| SCHEMBL30891387 | 0.90 | SIRT2 (0.75) | SIRT2SIRT1SIRT3MEN1ALDH1A1 | |
| SCHEMBL19156039 | 0.89 | SIRT2 (0.53) | SIRT2SIRT1SIRT3MEN1ALDH1A1 | |
| SCHEMBL24234674 | 0.87 | MMP2 (0.54) | SIRT2SIRT1SIRT3MEN1ALDH1A1 | |
| SCHEMBL12202911 | 0.86 | MEN1 (0.68) | SIRT2SIRT1SIRT3MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12427187-B2 | Glucose-responsive insulin conjugates | MERCK SHARP & DOHME LLC (US) | 2025-09-30 | — | — | US | disclosed |
| US-20220233647-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2022-07-28 | — | — | US | disclosed |
| EP-3980052-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2022-04-13 | — | — | EP | disclosed |
| WO-2020247297-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2020-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12427187-B2 | Glucose-responsive insulin conjugates | GPR119, IRS1, INSR | SIRT2 3319/4885SIRT1 1862/4885SIRT3 3516/4885 |
| US-20220233647-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | GPR119, IRS1, INSR | SIRT2 3319/4885SIRT1 1862/4885SIRT3 3516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.