SCHEMBL2275322

SCHEMBL2275322

CC(C)(C)OC(=O)c1ccc(-n2cnc3ccccc32)cc1NC(=O)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 2/20 0.52
ALDH1A1 P00352 2/20 0.48
GAA P10253 1/20 0.48
NR1H4 Q96RI1 1/20 0.46
LMNA P02545 1/20 0.46
HPGD P15428 1/20 0.46
RAB9A P51151 2/20 0.45
NPC1 O15118 1/20 0.45
RIPK1 Q13546 1/20 0.43
RIPK3 Q9Y572 1/20 0.43
PDE11A Q9HCR9 1/20 0.43
PDE10A Q9Y233 1/20 0.43
MAPT P10636 2/20 0.43
F9 P00740 1/20 0.42
F10 P00742 1/20 0.42
AURKA O14965 1/20 0.42
KDR P35968 1/20 0.42
AURKB Q96GD4 1/20 0.42
POLB P06746 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276731 0.85 MEN1 (0.51) FGFR1ALDH1A1GAANR1H4LMNA
Hydrochloric Acid SCHEMBL2270944 0.84 FGFR1 (0.50) FGFR1ALDH1A1GAANR1H4LMNA
SCHEMBL2273129 0.83 PDE11A (0.41) ALDH1A1NR1H4RAB9ANPC1PDE11A
SCHEMBL4218056 0.82 FGFR1 (0.47) FGFR1ALDH1A1LMNAHPGDRAB9A
SCHEMBL2273439 0.80 SERPINE1 (0.46) ALDH1A1LMNAHPGDRAB9ANPC1
SCHEMBL14428471 0.79 FGFR1 (0.51) FGFR1ALDH1A1GAALMNAHPGD
SCHEMBL2270158 0.78 MAPK1 (0.50) ALDH1A1NR1H4HPGDRAB9ANPC1
SCHEMBL17531409 0.75 FGFR1 (0.57) FGFR1ALDH1A1LMNAHPGDRAB9A
SCHEMBL2272788 0.75 NR1H4 (0.55) ALDH1A1NR1H4HPGDMAPT
SCHEMBL17531414 0.73 FGFR1 (0.58) FGFR1ALDH1A1RAB9ANPC1F9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 FGFR1 972/4885ALDH1A1 645/4885GAA 2590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.