Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 14/20 | 0.53 |
| ▸ | DRD2 | P14416 | 9/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22755049 | 0.94 | POLB (0.64) | POLBDRD4SIGMAR1 | |
| SCHEMBL22755067 | 0.81 | MDM4 (0.46) | POLB | |
| SCHEMBL22755258 | 0.77 | LIPG (0.48) | — | |
| SCHEMBL22755022 | 0.77 | LIPG (0.40) | POLB | |
| SCHEMBL13663256 | 0.76 | POLB (0.65) | POLBDRD4DRD2SIGMAR1MCHR1 | |
| SCHEMBL22755113 | 0.76 | ADORA2A (0.48) | — | |
| SCHEMBL2900272 | 0.75 | SIGMAR1 (0.86) | POLBDRD4DRD2SIGMAR1MCHR1 | |
| SCHEMBL22754845 | 0.75 | NPC1 (0.50) | POLB | |
| SCHEMBL22755092 | 0.75 | BACE1 (0.41) | — | |
| SCHEMBL14205981 | 0.74 | POLB (0.65) | POLBDRD4DRD2SIGMAR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3747885-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2020-12-09 | — | — | EP | disclosed |