Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ME3 | Q16798 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MAP3K6 | O95382 | 3/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22755049 | 0.85 | POLB (0.64) | POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL22755258 | 0.83 | LIPG (0.48) | ALDH1A1BACE1NPC1RAB9A | |
| SCHEMBL22755113 | 0.82 | ADORA2A (0.48) | SMN1; SMN2MEN1ALDH1A1KMT2ABACE1 | |
| SCHEMBL22754937 | 0.81 | POLB (0.56) | POLB | |
| SCHEMBL22754845 | 0.81 | NPC1 (0.50) | POLBSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL22755022 | 0.81 | LIPG (0.40) | POLBCNR2BACE1NPC1RAB9A | |
| SCHEMBL22755092 | 0.80 | BACE1 (0.41) | KMT2AEPHX2CNR2BACE1NPC1 | |
| SCHEMBL22755069 | 0.80 | NPY5R (0.41) | JAK1NPY5R | |
| SCHEMBL22755368 | 0.78 | MTNR1A (0.49) | ALDH1A1BACE1NPC1RAB9A | |
| SCHEMBL22755311 | 0.77 | MAPK14 (0.39) | ALDH1A1KMT2ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3747885-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2020-12-09 | — | — | EP | disclosed |