SCHEMBL2275720

SCHEMBL2275720

O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1cccc(-c2ccccc2)c1

nearest known ligand 0.73

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SUCNR1 Q9BXA5 2/20 0.73
ACLY P53396 4/20 0.72
SERPINE1 P05121 2/20 0.67
MEN1 O00255 2/20 0.65
PKM P14618 2/20 0.65
KMT2A Q03164 2/20 0.65
DHODH Q02127 1/20 0.63
HDAC1 Q13547 3/20 0.61
HDAC2 Q92769 3/20 0.61
HDAC3 O15379 1/20 0.60
GRIK1 P39086 2/20 0.59
MAPT P10636 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
HDAC8 Q9BY41 1/20 0.57
NPC1 O15118 1/20 0.56
RAB9A P51151 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275453 0.94 ACLY (0.76) SUCNR1ACLYSERPINE1MEN1PKM
SCHEMBL2272270 0.92 SUCNR1 (0.67) SUCNR1ACLYSERPINE1MEN1PKM
SCHEMBL2270222 0.91 DHODH (0.77) SUCNR1ACLYSERPINE1MEN1PKM
SCHEMBL2272416 0.90 ACLY (0.64) SUCNR1ACLYSERPINE1MEN1PKM
SCHEMBL2272881 0.90 HDAC1 (0.74) SUCNR1ACLYSERPINE1MEN1PKM
SCHEMBL2271703 0.90 ACLY (0.64) SUCNR1ACLYSERPINE1MEN1PKM
SCHEMBL2274100 0.90 ACLY (0.64) SUCNR1ACLYSERPINE1MEN1PKM
SCHEMBL2270137 0.90 GRIK1 (0.70) SUCNR1ACLYSERPINE1MEN1PKM
SCHEMBL2274563 0.90 ACLY (0.81) SUCNR1ACLYSERPINE1MEN1PKM
SCHEMBL2273186 0.88 ACLY (0.68) SUCNR1ACLYSERPINE1MEN1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 SUCNR1 637/4885ACLY 653/4885SERPINE1 101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.