SCHEMBL2275737

SCHEMBL2275737

Cc1cccc(Oc2ccc(C(=O)O)c(NC(=O)c3ccccc3)c2)c1C

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.60
ALDH1A1 P00352 1/20 0.60
GAA P10253 1/20 0.60
CRHBP P24387 1/20 0.60
FNTA P49354 1/20 0.60
FNTB P49356 1/20 0.60
CRHR2 Q13324 1/20 0.60
PYGM P11217 5/20 0.58
PYGL P06737 6/20 0.58
MEN1 O00255 3/20 0.50
PKM P14618 3/20 0.50
KMT2A Q03164 3/20 0.50
MAPT P10636 1/20 0.50
GRIK1 P39086 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
KCNK2 O95069 1/20 0.49
KCNK10 P57789 1/20 0.49
HPSE Q9Y251 1/20 0.49
NPSR1 Q6W5P4 1/20 0.48
HPGD P15428 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276583 0.92 PYGM (0.61) POLBPYGMPYGLMEN1PKM
SCHEMBL2272615 0.87 PYGM (0.55) POLBALDH1A1PYGMPYGLMEN1
SCHEMBL2269635 0.84 PYGM (0.56) PYGMPYGLMEN1PKMKMT2A
SCHEMBL2269896 0.83 TDP1 (0.58) PYGMPYGLMEN1PKMKMT2A
SCHEMBL2271528 0.82 PYGM (0.61) ALDH1A1PYGMPYGLMEN1PKM
SCHEMBL2271217 0.82 PYGM (0.61) PYGMPYGLMEN1PKMKMT2A
SCHEMBL2273166 0.82 GFER (0.61) ALDH1A1PYGMPYGLMEN1PKM
SCHEMBL2270304 0.82 MEN1 (0.61) PYGMPYGLMEN1PKMKMT2A
SCHEMBL2273044 0.82 CYP2C9 (0.61) ALDH1A1PYGMPYGLMEN1PKM
SCHEMBL2270688 0.81 PYGM (0.58) PYGMPYGLMEN1PKMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 POLB 3860/4885ALDH1A1 645/4885GAA 2590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.