Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718614 | 0.85 | MAOA (0.44) | MAOAMAOBKDM4EGPR3PDE4A | |
| SCHEMBL6345730 | 0.80 | USP5 (0.44) | MAOAMAOBERN1 | |
| SCHEMBL27552102 | 0.79 | MAOA (0.45) | MAOAMAOBKDM4EGPR3PDE4A | |
| SCHEMBL23027927 | 0.78 | GPR3 (0.45) | KDM4EGPR3LRRK2MPOERN1 | |
| SCHEMBL827432 | 0.78 | KDM4E (0.45) | KDM4EGPR3PDE4APDE4BPDE4C | |
| SCHEMBL21893819 | 0.78 | MAPT (0.52) | MAOAMAOBKDM4ELMNAERN1 | |
| SCHEMBL22758237 | 0.77 | KDM4E (0.48) | KDM4EGPR3PDE4APDE4BPDE4C | |
| SCHEMBL21364626 | 0.77 | KDM4E (0.44) | KDM4EGPR3LRRK2MPOLMNA | |
| SCHEMBL30409628 | 0.76 | MAOA (0.50) | MAOAMAOBKDM4EGPR3PDE4A | |
| SCHEMBL2125593 | 0.76 | MAOA (0.50) | MAOAMAOBKDM4EGPR3PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11248007-B2 | Inhibitors of MALT1 and uses thereof | CORNELL UNIVERSITY (US) | 2022-02-15 | — | — | US | disclosed |
| US-20200385405-A1 | INHIBITORS OF MALT1 AND USES THEREOF | CORNELL UNIVERSITY (US) | 2020-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200385405-A1 | INHIBITORS OF MALT1 AND USES THEREOF | MALT1, BCL6, BCL3 | MAOA 4302/4885MAOB 3524/4885KDM4E 1844/4885 |
| US-11248007-B2 | Inhibitors of MALT1 and uses thereof | MALT1, BCL6, BCL3 | MAOA 4302/4885MAOB 3524/4885KDM4E 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.