Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GPR3 | P46089 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL827432 | 0.78 | KDM4E (0.45) | KDM4EGPR3LRRK2MPOERN1 | |
| SCHEMBL23027927 | 0.78 | GPR3 (0.45) | KDM4EGPR3LRRK2MPOERN1 | |
| SCHEMBL14205601 | 0.78 | MAPT (0.52) | KDM4EERN1ALOX5APFEN1MET | |
| SCHEMBL21364626 | 0.77 | KDM4E (0.44) | KDM4EGPR3LRRK2MPOERN1 | |
| SCHEMBL22758231 | 0.77 | MAOA (0.47) | KDM4EGPR3LRRK2MPOERN1 | |
| SCHEMBL22758306 | 0.77 | KDM4E (0.40) | KDM4EGPR3LRRK2MPOTLR7 | |
| SCHEMBL23474020 | 0.76 | GPR3 (0.52) | KDM4EGPR3ERN1SMN1; SMN2TLR7 | |
| SCHEMBL12880445 | 0.75 | PARP1 (0.39) | ALOX5APFEN1 | |
| SCHEMBL22758192 | 0.74 | KDM4E (0.41) | KDM4EGPR3LRRK2MPOERN1 | |
| SCHEMBL18368376 | 0.73 | ALOX5AP (0.36) | KDM4EGPR3ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11248007-B2 | Inhibitors of MALT1 and uses thereof | CORNELL UNIVERSITY (US) | 2022-02-15 | — | — | US | disclosed |
| US-20200385405-A1 | INHIBITORS OF MALT1 AND USES THEREOF | CORNELL UNIVERSITY (US) | 2020-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200385405-A1 | INHIBITORS OF MALT1 AND USES THEREOF | MALT1, BCL6, BCL3 | KDM4E 1844/4885GPR3 3780/4885LRRK2 1397/4885 |
| US-11248007-B2 | Inhibitors of MALT1 and uses thereof | MALT1, BCL6, BCL3 | KDM4E 1844/4885GPR3 3780/4885LRRK2 1397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.