Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.36 |
| ▸ | CDK2 | P24941 | 4/20 | 0.36 |
| ▸ | CDK4 | P11802 | 3/20 | 0.36 |
| ▸ | CCND1 | P24385 | 3/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22758200 | 0.79 | MALT1 (0.40) | KDM4EGPR3LRRK2MPOPOLB | |
| SCHEMBL11161720 | 0.79 | KDM4E (0.42) | KDM4EGPR3TLR7CCNE2CCNE1 | |
| SCHEMBL22758237 | 0.77 | KDM4E (0.48) | KDM4EGPR3TLR7LRRK2MPO | |
| SCHEMBL24910161 | 0.75 | NR1H2 (0.35) | TLR7ADORA2ACCNE2CCNE1CDK2 | |
| SCHEMBL24910165 | 0.75 | POLB (0.39) | KDM4EGPR3TLR7ADORA2ALRRK2 | |
| SCHEMBL23027927 | 0.74 | GPR3 (0.45) | KDM4EGPR3TLR7LRRK2MPO | |
| SCHEMBL827432 | 0.74 | KDM4E (0.45) | KDM4EGPR3TLR7LRRK2MPO | |
| SCHEMBL22758231 | 0.73 | MAOA (0.47) | KDM4EGPR3LRRK2MPO | |
| SCHEMBL21364626 | 0.73 | KDM4E (0.44) | KDM4EGPR3LRRK2MPOCYP1A2 | |
| SCHEMBL16132395 | 0.72 | KDM4E (0.40) | KDM4EGPR3TLR7ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11248007-B2 | Inhibitors of MALT1 and uses thereof | CORNELL UNIVERSITY (US) | 2022-02-15 | — | — | US | disclosed |
| US-20200385405-A1 | INHIBITORS OF MALT1 AND USES THEREOF | CORNELL UNIVERSITY (US) | 2020-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200385405-A1 | INHIBITORS OF MALT1 AND USES THEREOF | MALT1, BCL6, BCL3 | KDM4E 1844/4885GPR3 3780/4885TLR7 3989/4885 |
| US-11248007-B2 | Inhibitors of MALT1 and uses thereof | MALT1, BCL6, BCL3 | KDM4E 1844/4885GPR3 3780/4885TLR7 3989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.