Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760357 | 0.95 | REN (0.38) | RENALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL22747915 | 0.91 | ALDH1A1 (0.40) | RENALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL22747873 | 0.89 | MAT2A (0.43) | ALDH1A1HPGDGAAMEN1KMT2A | |
| SCHEMBL22760176 | 0.86 | REN (0.38) | RENALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL22760356 | 0.84 | MAT2A (0.43) | ALDH1A1HPGDGAAMEN1KMT2A | |
| SCHEMBL22747827 | 0.83 | SMN1; SMN2 (0.42) | ALDH1A1HPGDHSD17B10GAAMEN1 | |
| SCHEMBL22748254 | 0.82 | MAT2A (0.46) | RENEDNRAFABP3FABP4FABP5 | |
| SCHEMBL22760383 | 0.82 | GAA (0.32) | RENALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL22748265 | 0.81 | HPGD (0.40) | RENALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL22760058 | 0.81 | ALDH1A1 (0.39) | ALDH1A1HPGDGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |