Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22748265 | 0.91 | HPGD (0.40) | RENHPGDHSD17B10GAAMEN1 | |
| SCHEMBL22760046 | 0.86 | REN (0.38) | RENHPGDHSD17B10GAAMEN1 | |
| SCHEMBL22760357 | 0.84 | REN (0.38) | RENHPGDHSD17B10GAAMEN1 | |
| SCHEMBL22747915 | 0.81 | ALDH1A1 (0.40) | RENHPGDHSD17B10GAAMEN1 | |
| SCHEMBL22760057 | 0.79 | SMN1; SMN2 (0.39) | HPGDHSD17B10GAAMEN1KMT2A | |
| SCHEMBL22747842 | 0.78 | HPGD (0.37) | HPGDHSD17B10GAAMEN1KMT2A | |
| SCHEMBL22760542 | 0.78 | GAA (0.37) | RENHPGDHSD17B10GAAMEN1 | |
| SCHEMBL22748254 | 0.78 | MAT2A (0.46) | RENMAT2AEDNRAMAPK8MAPK9 | |
| SCHEMBL22760546 | 0.77 | HPGD (0.40) | HPGDHSD17B10GAAMEN1KMT2A | |
| SCHEMBL22760118 | 0.75 | GAA (0.38) | RENHPGDHSD17B10GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |