Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.41 |
| ▸ | MAT2A | P31153 | 3/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760346 | 0.92 | FOLH1 (0.45) | FOLH1MAT2APRMT5CYP1A2MAPK8 | |
| SCHEMBL22747867 | 0.91 | MAPK8 (0.40) | NOTUMFOLH1MAT2APRMT5CYP1A2 | |
| SCHEMBL22747838 | 0.89 | NOTUM (0.42) | NOTUMFOLH1MAPK8TSHRMEN1 | |
| SCHEMBL22760373 | 0.85 | FOLH1 (0.36) | NOTUMFOLH1MAT2APRMT5CYP1A2 | |
| SCHEMBL22760375 | 0.85 | NOTUM (0.37) | NOTUMFOLH1CYP1A2LMNATSHR | |
| SCHEMBL22760073 | 0.84 | CENPE (0.39) | NOTUMFOLH1MAT2AMAPK8MEN1 | |
| SCHEMBL22760319 | 0.83 | MAT2A (0.51) | MAT2APRMT5CYP1A2MAPK8MAPK9 | |
| SCHEMBL22760374 | 0.83 | HTT (0.33) | NOTUMFOLH1 | |
| SCHEMBL22760442 | 0.83 | EDNRA (0.50) | FOLH1MAT2APRMT5CYP1A2MAPK8 | |
| SCHEMBL22747849 | 0.83 | FOLH1 (0.39) | FOLH1MAT2APRMT5CYP1A2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |