Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RPA1 | P27694 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760346 | 0.90 | FOLH1 (0.45) | FOLH1MAPTALDH1A1LMNATSHR | |
| SCHEMBL22760073 | 0.89 | CENPE (0.39) | NOTUMFOLH1SMN1; SMN2TDP1MEN1 | |
| SCHEMBL22760374 | 0.89 | HTT (0.33) | NOTUMFOLH1HTTTDP1TP53 | |
| SCHEMBL22760067 | 0.87 | EDNRA (0.41) | FOLH1MAPTHTTALDH1A1RPA1 | |
| SCHEMBL22760140 | 0.85 | NOTUM (0.41) | NOTUMFOLH1ALDH1A1LMNATSHR | |
| SCHEMBL22760373 | 0.84 | FOLH1 (0.36) | NOTUMFOLH1RPA1MYCNR4A1 | |
| SCHEMBL22760365 | 0.81 | FOLH1 (0.42) | FOLH1HTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL22747914 | 0.81 | MAPK8 (0.40) | FOLH1CYP1A2 | |
| SCHEMBL22747826 | 0.81 | NOTUM (0.40) | NOTUMMAPTSMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL22747870 | 0.81 | FOLH1 (0.42) | FOLH1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |