Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760375 | 0.89 | NOTUM (0.37) | NOTUMSMN1; SMN2FOLH1TDP1MEN1 | |
| SCHEMBL22760346 | 0.89 | FOLH1 (0.45) | MAPK8MAT2AFOLH1 | |
| SCHEMBL22760067 | 0.86 | EDNRA (0.41) | MAPK8FOLH1PPARGMEN1KMT2A | |
| SCHEMBL22747914 | 0.85 | MAPK8 (0.40) | CENPEMAPK8MAT2AFOLH1 | |
| SCHEMBL22747870 | 0.85 | FOLH1 (0.42) | MAPK8MAT2AFOLH1 | |
| SCHEMBL22760140 | 0.84 | NOTUM (0.41) | NOTUMMAPK8MAT2AFOLH1MEN1 | |
| SCHEMBL22760374 | 0.83 | HTT (0.33) | NOTUMFOLH1TDP1 | |
| SCHEMBL22760373 | 0.83 | FOLH1 (0.36) | NOTUMMAPK8MAT2AFOLH1PPARG | |
| SCHEMBL22760068 | 0.81 | CENPE (0.38) | CENPENOTUMSMN1; SMN2MAPK8KCNH2 | |
| SCHEMBL22760065 | 0.81 | JAK2 (0.44) | SMN1; SMN2MAPK8FOLH1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |