Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.37 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760364 | 0.86 | FOLH1 (0.37) | NOTUMMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL22760424 | 0.86 | P2RX7 (0.35) | NOTUMCCR2P2RX7PLA2G4AALOX15 | |
| SCHEMBL22747826 | 0.82 | NOTUM (0.40) | NOTUMMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL22760379 | 0.81 | SMN1; SMN2 (0.35) | NOTUMMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL22747882 | 0.81 | HTT (0.37) | NOTUMMAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL22760158 | 0.80 | NOTUM (0.41) | NOTUMALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL22760144 | 0.79 | RPA1 (0.36) | NOTUMMAPTSMN1; SMN2TP53KDM4E | |
| SCHEMBL22760068 | 0.78 | CENPE (0.38) | NOTUMMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL22747865 | 0.76 | FOLH1 (0.35) | MAPTALDH1A1SMN1; SMN2TP53MEN1 | |
| SCHEMBL22747829 | 0.76 | FOLH1 (0.35) | NOTUMMAPTALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |