Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22748436 | 0.90 | MAPK8 (0.46) | MAPK8NPBWR1MCHR1GPR119USP30 | |
| SCHEMBL22760097 | 0.85 | CHRM4 (0.45) | MCHR1MEN1KMT2A | |
| SCHEMBL22747899 | 0.75 | HTR1A (0.40) | — | |
| SCHEMBL22760385 | 0.75 | MAPK8 (0.49) | MAPK8GPR119MEN1KMT2ATP53 | |
| SCHEMBL22747874 | 0.75 | MAPT (0.43) | MEN1KMT2ATP53MAPT | |
| SCHEMBL1769219 | 0.72 | USP30 (0.71) | GPR119USP30PIK3CDPRMT5WDR77 | |
| SCHEMBL21409063 | 0.72 | USP30 (0.71) | GPR119USP30PIK3CDPRMT5WDR77 | |
| SCHEMBL5153452 | 0.72 | USP30 (0.71) | GPR119USP30PIK3CDPRMT5WDR77 | |
| SCHEMBL21483739 | 0.70 | PDE4B (0.48) | NPBWR1MCHR1GPR119USP30PIK3CD | |
| SCHEMBL5835368 | 0.70 | PDE4B (0.48) | NPBWR1MCHR1GPR119USP30PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |