Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 5/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22747874 | 0.88 | MAPT (0.43) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL22760191 | 0.85 | MAPK8 (0.46) | MEN1KMT2AMCHR1 | |
| SCHEMBL22747899 | 0.81 | HTR1A (0.40) | HTR2CHTR2BFOLH1UTS2RSLC6A2 | |
| SCHEMBL22748436 | 0.75 | MAPK8 (0.46) | ALDH1A1MEN1KMT2AMCHR1 | |
| SCHEMBL22760197 | 0.72 | MAPT (0.42) | ALDH1A1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL22760511 | 0.71 | MAPK8 (0.38) | ALDH1A1CYP1A2CCR3 | |
| SCHEMBL22747915 | 0.69 | ALDH1A1 (0.40) | ALDH1A1FOLH1MEN1KMT2A | |
| SCHEMBL22760110 | 0.68 | VCP (0.36) | FOLH1KMT2AHRH1CCR3KCNH2 | |
| SCHEMBL22747863 | 0.67 | MAT2A (0.47) | ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL22760346 | 0.66 | FOLH1 (0.45) | ALDH1A1CYP1A2FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |