Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | RPA1 | P27694 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22747822 | 0.88 | GAA (0.38) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL22760495 | 0.87 | FOLH1 (0.37) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL22748438 | 0.86 | SMN1; SMN2 (0.43) | RAB9ASMN1; SMN2MEN1KMT2ACNR2 | |
| SCHEMBL22747824 | 0.84 | EDNRA (0.40) | MAPTRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL22747828 | 0.83 | NOTUM (0.39) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL22747903 | 0.83 | RAB9A (0.38) | MAPTRAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL22748447 | 0.83 | USP14 (0.39) | MAPTRAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL22747839 | 0.82 | TSHR (0.43) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL22760308 | 0.78 | GAA (0.40) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL22747864 | 0.78 | CCR2 (0.46) | MAPTPOLBMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |