Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 4/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760127 | 0.86 | NOTUM (0.37) | P2RX7ALOX15NOTUMCCR2PLA2G4A | |
| SCHEMBL22760364 | 0.83 | FOLH1 (0.37) | NOTUMCCR2 | |
| SCHEMBL22760358 | 0.83 | KRAS (0.37) | P2RX7ALOX15NOTUMCCR2KRAS | |
| SCHEMBL22760144 | 0.79 | RPA1 (0.36) | HTR1ANOTUMCCR2 | |
| SCHEMBL22747882 | 0.78 | HTT (0.37) | NOTUMCCR2 | |
| SCHEMBL22760158 | 0.77 | NOTUM (0.41) | NOTUM | |
| SCHEMBL22760379 | 0.77 | SMN1; SMN2 (0.35) | NOTUMPPARG | |
| SCHEMBL22760068 | 0.76 | CENPE (0.38) | NOTUMCCR2PPARG | |
| SCHEMBL22760070 | 0.73 | FOLH1 (0.35) | CCR2 | |
| SCHEMBL22747829 | 0.73 | FOLH1 (0.35) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |