SCHEMBL2276160

SCHEMBL2276160

Cc1cccc(C(=O)Nc2cc(-c3cc4ccccc4o3)ccc2C(=O)OC(C)(C)C)c1C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.49
MAOA P21397 4/20 0.49
HDAC2 Q92769 1/20 0.46
RAB9A P51151 6/20 0.44
NPC1 O15118 5/20 0.44
BACE1 P56817 2/20 0.43
MEN1 O00255 2/20 0.42
ALDH1A1 P00352 2/20 0.42
KMT2A Q03164 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
TP53 P04637 2/20 0.42
KDM4E B2RXH2 1/20 0.42
NFKB1 P19838 1/20 0.42
NPY1R P25929 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
P2RY14 Q15391 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275333 0.86 MAOB (0.54) MAOBMAOAHDAC2RAB9ANPC1
SCHEMBL12394956 0.83 MAOB (0.53) MAOBMAOAHDAC2RAB9ANPC1
SCHEMBL2276764 0.82 HDAC2 (0.54) MAOBHDAC2RAB9ANPC1BACE1
SCHEMBL2269657 0.79 ALDH1A1 (0.45) RAB9ANPC1MEN1ALDH1A1KMT2A
SCHEMBL2272608 0.77 ALDH1A1 (0.47) RAB9ANPC1MEN1ALDH1A1KMT2A
SCHEMBL2272065 0.77 ALDH1A1 (0.40) MAOBRAB9ANPC1MEN1ALDH1A1
SCHEMBL2274762 0.76 HDAC2 (0.48) MAOBMAOAHDAC2RAB9ANPC1
SCHEMBL2273301 0.76 MAPT (0.40) RAB9ANPC1MEN1ALDH1A1KMT2A
SCHEMBL12369426 0.75 HDAC2 (0.69) MAOBHDAC2RAB9ANPC1MEN1
SCHEMBL2272611 0.74 MAPT (0.35) RAB9ANPC1MEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MAOB 1486/4885MAOA 802/4885HDAC2 276/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.