SCHEMBL2276597

SCHEMBL2276597

COc1ccc(Cl)cc1-c1ccc(C(=O)O)c(NC(=O)c2ccccc2)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.61
KMT2A Q03164 2/20 0.61
PKM P14618 1/20 0.61
NPSR1 Q6W5P4 1/20 0.61
SERPINE1 P05121 4/20 0.57
GRIK1 P39086 3/20 0.57
ACLY P53396 3/20 0.56
NPC1 O15118 1/20 0.56
ALDH1A1 P00352 1/20 0.56
HTT P42858 1/20 0.56
RAB9A P51151 1/20 0.56
KCNH2 Q12809 1/20 0.56
CHEK1 O14757 1/20 0.53
PIM1 P11309 1/20 0.53
MAPK8 P45983 1/20 0.53
CLK4 Q9HAZ1 1/20 0.53
MAPT P10636 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
MAPK1 P28482 2/20 0.52
KDM4E B2RXH2 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2273065 0.87 MAPK1 (0.57) MEN1KMT2APKMNPSR1GRIK1
SCHEMBL2272986 0.85 SERPINE1 (0.60) MEN1KMT2APKMNPSR1SERPINE1
SCHEMBL2271453 0.85 KMT2A (0.69) MEN1KMT2APKMNPSR1GRIK1
SCHEMBL2272873 0.85 SERPINE1 (0.63) MEN1KMT2APKMNPSR1SERPINE1
SCHEMBL2270946 0.84 SERPINE1 (0.62) MEN1KMT2APKMNPSR1SERPINE1
SCHEMBL2270146 0.83 CHEK1 (0.67) MEN1KMT2APKMGRIK1ACLY
SCHEMBL27848589 0.83 ACLY (0.59) MEN1KMT2APKMNPSR1GRIK1
SCHEMBL5146969 0.82 SERPINE1 (0.63) MEN1KMT2APKMNPSR1SERPINE1
SCHEMBL2272049 0.81 ACLY (0.78) MEN1KMT2APKMNPSR1SERPINE1
SCHEMBL1310106 0.80 GRIK1 (0.74) MEN1KMT2APKMNPSR1SERPINE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MEN1 3105/4885KMT2A 1669/4885PKM 2367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.