SCHEMBL2277779

SCHEMBL2277779

CC(C)Oc1ccc(-c2ccc(C(=O)O)c(NC(=O)c3ccccc3)c2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACLY P53396 3/20 0.57
ALDH1A1 P00352 2/20 0.55
HDAC2 Q92769 3/20 0.55
MEN1 O00255 2/20 0.52
PKM P14618 2/20 0.52
KMT2A Q03164 2/20 0.52
MAPT P10636 2/20 0.52
TDP1 Q9NUW8 2/20 0.52
GRIK1 P39086 1/20 0.52
DHODH Q02127 1/20 0.52
HDAC1 Q13547 3/20 0.51
ADCY1 Q08828 1/20 0.51
PRSS12 P56730 2/20 0.50
NPSR1 Q6W5P4 1/20 0.50
RXRA P19793 1/20 0.50
RXRB P28702 1/20 0.50
HDAC3 O15379 1/20 0.50
IGF2BP2 Q9Y6M1 1/20 0.49
GALK1 P51570 1/20 0.49
CASP6 P55212 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275393 0.86 HDAC2 (0.73) ACLYALDH1A1HDAC2MEN1PKM
SCHEMBL1319062 0.85 ACLY (0.52) ACLYALDH1A1HDAC2TDP1HDAC1
SCHEMBL2272033 0.85 ACLY (0.62) ACLYHDAC2MEN1PKMKMT2A
SCHEMBL2275453 0.84 ACLY (0.76) ACLYHDAC2MEN1PKMKMT2A
SCHEMBL27696827 0.84 ACLY (0.64) ACLYHDAC2MEN1PKMKMT2A
SCHEMBL2269612 0.83 HDAC1 (0.53) ACLYMEN1PKMKMT2AMAPT
SCHEMBL2269165 0.82 MEN1 (0.69) ACLYALDH1A1HDAC2MEN1PKM
SCHEMBL4563581 0.82 ACLY (0.65) ACLYALDH1A1HDAC2MEN1PKM
SCHEMBL2273186 0.82 ACLY (0.68) ACLYHDAC2MEN1PKMKMT2A
SCHEMBL2270222 0.81 DHODH (0.77) ACLYHDAC2MEN1PKMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ACLY 653/4885ALDH1A1 645/4885HDAC2 276/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.