Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.57 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | S100A4 | P26447 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9840644 | 0.90 | KIF18A (0.51) | KIF18ACNR2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2742908 | 0.85 | CYP3A4 (0.48) | KIF18ACNR2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL228959 | 0.85 | KIF18A (0.57) | KIF18ACNR2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13309929 | 0.81 | KIF18A (0.58) | KIF18ACNR2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11212056 | 0.81 | HTR6 (0.61) | KIF18ACNR2MAPTHTR6PKM | |
| SCHEMBL2462163 | 0.81 | KIF18A (0.61) | KIF18ACNR2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9452112 | 0.80 | HTT (0.49) | KIF18ACNR2GAAKDM4EPGR | |
| SCHEMBL10670726 | 0.79 | KIF18A (0.55) | KIF18ACNR2MAPTNPSR1ALDH1A1 | |
| SCHEMBL1465612 | 0.79 | KIF18A (0.51) | KIF18ACNR2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL27480676 | 0.79 | KIF18A (0.51) | KIF18ACNR2NPSR1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519554-B1 | POLYARYLENE POLYMERS AND PROCESSES FOR PREPARING | DU PONT (US) | 2016-03-16 | — | — | EP | disclosed |
| US-8609804-B2 | Polyarylene polymers and processes for preparing | E I DU PONT DE NEMOURS AND COMPANY (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120322973-A1 | POLYARYLENE POLYMERS AND PROCESSES FOR PREPARING | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-12-20 | — | — | US | disclosed |
| US-20120322973-A1 | POLYARYLENE POLYMERS AND PROCESSES FOR PREPARING | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-12-20 | — | — | US | disclosed |
| EP-2519554-A2 | POLYARYLENE POLYMERS AND PROCESSES FOR PREPARING | E.I. Du Pont De Nemours And Company (US) | 2012-11-07 | — | — | EP | disclosed |
| US-20120004387-A1 | POLYARYLENE POLYMERS AND PROCESSES FOR PREPARING | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-01-05 | — | — | US | disclosed |
| US-20120004387-A1 | POLYARYLENE POLYMERS AND PROCESSES FOR PREPARING | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-01-05 | — | — | US | disclosed |
| WO-2011090705-A2 | POLYARYLENE POLYMERS AND PROCESSES FOR PREPARING | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-07-28 | — | — | WO | disclosed |
| WO-2011090705-A2 | POLYARYLENE POLYMERS AND PROCESSES FOR PREPARING | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004387-A1 | POLYARYLENE POLYMERS AND PROCESSES FOR PREPARING | PCBP1, PARG, PARN | KIF18A 1958/4885CNR2 3293/4885CYP3A4 578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.