Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL416047 | 0.89 | ABHD6 (0.48) | NOTUMABHD6MEN1MAPTKMT2A | |
| SCHEMBL417106 | 0.89 | ABHD6 (0.48) | NOTUMABHD6MEN1MAPTKMT2A | |
| SCHEMBL14393093 | 0.89 | ABHD6 (0.48) | NOTUMABHD6MEN1MAPTKMT2A | |
| SCHEMBL30132306 | 0.87 | NOTUM (0.57) | NOTUMABHD6MEN1MAPTKMT2A | |
| SCHEMBL22784496 | 0.86 | NOTUM (0.50) | NOTUMABHD6MEN1MAPTKMT2A | |
| SCHEMBL28825998 | 0.84 | KEAP1 (0.61) | NOTUMABHD6MEN1MAPTKMT2A | |
| SCHEMBL417099 | 0.83 | NOTUM (0.50) | NOTUMABHD6MEN1MAPTKMT2A | |
| SCHEMBL417107 | 0.83 | NOTUM (0.50) | NOTUMABHD6MEN1MAPTKMT2A | |
| SCHEMBL22784355 | 0.82 | NOTUM (0.55) | NOTUMABHD6MEN1MAPTKMT2A | |
| SCHEMBL23562405 | 0.79 | ABHD6 (0.48) | NOTUMABHD6MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |