Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | SCN1A | P35498 | 2/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13951292 | 0.93 | CHRM4 (0.52) | NOTUMKMT2AMEN1CHRM3CHRM4 | |
| SCHEMBL30132306 | 0.91 | NOTUM (0.57) | NOTUMKMT2AMEN1KEAP1ABHD6 | |
| SCHEMBL28825998 | 0.89 | KEAP1 (0.61) | NOTUMKMT2AMEN1KEAP1ABHD6 | |
| SCHEMBL22784496 | 0.85 | NOTUM (0.50) | NOTUMKMT2AMEN1KEAP1ABHD6 | |
| SCHEMBL14143372 | 0.83 | ABHD6 (0.48) | NOTUMKMT2AMEN1KEAP1ABHD6 | |
| SCHEMBL22785136 | 0.82 | NOTUM (0.53) | NOTUMKMT2AMEN1KEAP1ABHD6 | |
| SCHEMBL14877516 | 0.81 | NOTUM (0.49) | NOTUMKMT2AMEN1KEAP1ABHD6 | |
| SCHEMBL22784273 | 0.80 | MEN1 (0.57) | NOTUMKMT2AMEN1MAPTTAAR1 | |
| SCHEMBL14393093 | 0.80 | ABHD6 (0.48) | NOTUMKMT2AMEN1KEAP1ABHD6 | |
| SCHEMBL3717443 | 0.80 | PRMT5 (0.52) | NOTUMKMT2AMEN1KEAP1ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |