Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 3/20 | 0.41 |
| ▸ | TKT | P29401 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 3/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.36 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1145551 | 0.81 | TRPV4 (0.47) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL1145542 | 0.77 | TRPV4 (0.47) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL688551 | 0.77 | DAO (0.50) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL19764842 | 0.77 | TRPV4 (0.43) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL20373734 | 0.75 | TSHR (0.41) | CSF1R | |
| SCHEMBL1819962 | 0.75 | DAO (0.47) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL91511 | 0.74 | TRPV4 (0.52) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL22775173 | 0.74 | CA2 (0.42) | TRPV4DAOTKTMRGPRX4PPARD | |
| SCHEMBL2608888 | 0.74 | TRPV4 (0.41) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL171861 | 0.74 | MRGPRX4 (0.47) | MAOBMRGPRX4GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020249785-A1 | SUBSTITUTED HETEROAROMATIC PYRAZOLO-PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |