Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.37 |
| ▸ | IL1B | P01584 | 7/20 | 0.37 |
| ▸ | PDE4A | P27815 | 4/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22791280 | 0.94 | P2RX7 (0.39) | P2RX7IL1BADAMTS4CNR1CNR2 | |
| SCHEMBL22791412 | 0.92 | PDE4A (0.35) | P2RX7IL1BPDE4APDE4BPDE4C | |
| SCHEMBL22791408 | 0.86 | P2RX7 (0.37) | P2RX7IL1BADAMTS4CNR1CNR2 | |
| SCHEMBL22776643 | 0.85 | P2RX7 (0.38) | P2RX7IL1BPDE4APDE4BPDE4C | |
| SCHEMBL22791483 | 0.85 | FPR1 (0.32) | IDH1OPRL1 | |
| SCHEMBL22791342 | 0.81 | PDE4A (0.35) | P2RX7IL1BPDE4APDE4BPDE4C | |
| SCHEMBL22776591 | 0.79 | P2RX7 (0.40) | P2RX7IL1BCNR1CNR2 | |
| SCHEMBL22777090 | 0.79 | PDE4A (0.37) | P2RX7IL1BPDE4APDE4BPDE4C | |
| SCHEMBL22791469 | 0.79 | GSK3B (0.38) | OPRL1 | |
| SCHEMBL22776532 | 0.77 | NR4A2 (0.50) | P2RX7IL1BPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251957-A1 | PROSTAGLANDIN E2 RECEPTOR 4 ANTAGONISTS AND USES THEREOF | TEON THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |