Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22776540 | 0.90 | PTGER4 (0.42) | PTGER4KDM4EALDH1A1PTGDR2SRD5A2 | |
| SCHEMBL22791244 | 0.89 | PTGER4 (0.36) | PTGER4KDM4EALDH1A1SMN1; SMN2RPS6KB1 | |
| SCHEMBL22776444 | 0.87 | PTGER4 (0.39) | PTGER4MEN1KMT2AKDM4EPTGDR2 | |
| SCHEMBL22791390 | 0.84 | KDM4E (0.35) | PTGER4KDM4EALDH1A1SMN1; SMN2RPS6KB1 | |
| SCHEMBL22776589 | 0.79 | PTGER4 (0.41) | PTGER4PTGDR2SRD5A2NPY5R | |
| SCHEMBL22791290 | 0.79 | PTGDR2 (0.41) | PTGER4PTGDR2 | |
| SCHEMBL22791289 | 0.79 | PTGDR2 (0.41) | PTGER4PTGDR2 | |
| SCHEMBL22791152 | 0.79 | PTGDR2 (0.41) | PTGER4PTGDR2 | |
| SCHEMBL29614425 | 0.78 | PTGER4 (0.36) | PTGER4PTGDR2NPY5R | |
| SCHEMBL22791205 | 0.78 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2RPS6KB1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251957-A1 | PROSTAGLANDIN E2 RECEPTOR 4 ANTAGONISTS AND USES THEREOF | TEON THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |