Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | RAD52 | P43351 | 2/20 | 0.61 |
| ▸ | DEGS1 | O15121 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 6/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.49 |
| ▸ | WNT1 | P04628 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22791546 | 0.83 | ALDH1A1 (0.57) | ALDH1A1KDM4EPOLBGAAMAPT | |
| SCHEMBL17450650 | 0.82 | RAB9A (0.56) | ALDH1A1KDM4EPOLBMAPTTSHR | |
| SCHEMBL15972102 | 0.82 | RAD52 (0.54) | ALDH1A1KDM4EPOLBRAD52TSHR | |
| SCHEMBL21286268 | 0.80 | ALDH1A1 (0.66) | ALDH1A1KDM4EPOLBGAAMAPT | |
| SCHEMBL17450652 | 0.80 | RAB9A (0.57) | ALDH1A1KDM4EPOLBMAPTTSHR | |
| SCHEMBL15986894 | 0.80 | RAD52 (0.56) | ALDH1A1KDM4EPOLBRAD52DEGS1 | |
| SCHEMBL22791611 | 0.80 | ALDH1A1 (0.91) | ALDH1A1KDM4EPOLBGAAMAPT | |
| Hydrochloric Acid SCHEMBL22777896 | 0.78 | ALDH1A1 (0.89) | ALDH1A1KDM4EPOLBGAAMAPT | |
| SCHEMBL15986675 | 0.78 | TSHR (0.52) | ALDH1A1KDM4ETSHRGSK3BDYRK1A | |
| SCHEMBL18453953 | 0.77 | MAPT (0.44) | ALDH1A1KDM4EPOLBGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220356176-A1 | Kv11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-11-10 | — | — | US | disclosed |
| WO-2020252130-A1 | KV11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | LIEBER INSTITUTE, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220356176-A1 | Kv11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | KCNAB1, KCNMA1, KCNA1 | ALDH1A1 1489/4885KDM4E 2187/4885POLB 4307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.