Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAOA | P21397 | 7/20 | 0.51 |
| ▸ | MAOB | P27338 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2281419 | 0.83 | MAOA (0.55) | SMN1; SMN2MAOAMAOBNPC1RAB9A | |
| SCHEMBL385690 | 0.82 | PPARA (0.58) | SMN1; SMN2MAOAMAOBNPC1RAB9A | |
| SCHEMBL353914 | 0.81 | MAOA (0.61) | MAOAMAOBNPC1RAB9ATDP1 | |
| SCHEMBL6538464 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL1959473 | 0.80 | CYSLTR2 (0.57) | MAOAMAOBNPC1RAB9ATDP1 | |
| SCHEMBL2285133 | 0.80 | MAOA (0.55) | SMN1; SMN2MAOAMAOBNPC1RAB9A | |
| SCHEMBL1955902 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL791810 | 0.80 | LMNA (0.68) | SMN1; SMN2NPC1RAB9ATDP1KDM4E | |
| SCHEMBL17710816 | 0.80 | MAOA (0.55) | SMN1; SMN2MAOAMAOBNPC1RAB9A | |
| SCHEMBL12217570 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2RAB9ATDP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |
| US-20060211680-A1 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-09-21 | — | — | US | disclosed |
| EP-1671948-A1 | CINNAMOYL COMPOUND AND USE OF THE SAME | Sumitomo Chemical Company, Limited (JP) | 2006-06-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211680-A1 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | COL2A1, COL1A1, COL14A1 | SMN1; SMN2 3766/4885MAOA 3666/4885MAOB 3699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.