Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 4/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23484599 | 0.83 | GABRG2 (0.51) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL22214048 | 0.80 | GABRG2 (0.49) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL22313714 | 0.80 | GABRG2 (0.49) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL22797385 | 0.79 | S1PR1 (0.49) | CYP2A6 | |
| SCHEMBL22313025 | 0.76 | GABRG2 (0.45) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL29431751 | 0.75 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL47861 | 0.74 | TSHR (0.56) | HSD17B1HSD17B2KDM1ATSHRCASP1 | |
| SCHEMBL25104842 | 0.74 | CYP11B1 (0.41) | GABRG2GABRB3GABRA5GABRA3CYP11B1 | |
| SCHEMBL22313758 | 0.73 | GABRG2 (0.42) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL5153274 | 0.72 | ESR2 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025130-A1 | METHODS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2023-01-26 | — | — | US | disclosed |
| US-11129829-B2 | Methods for modulating splicing | SKYHAWK THERAPEUTICS, INC. (US) | 2021-09-28 | — | — | US | disclosed |
| US-20200390765-A1 | METHODS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11129829-B2 | Methods for modulating splicing | RBM17, SNRPE, SNRPB2 | GABRG2 1813/4885GABRB3 1127/4885GABRA5 2293/4885 |
| US-20230025130-A1 | METHODS FOR MODULATING SPLICING | RBM17, SNRPE, SNRPB2 | GABRG2 1813/4885GABRB3 1127/4885GABRA5 2293/4885 |
| US-20200390765-A1 | METHODS FOR MODULATING SPLICING | RBM17, SNRPE, SNRPB2 | GABRG2 1813/4885GABRB3 1127/4885GABRA5 2293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.