Sugi Predict

Sugi Predict / Compounds / SCHEMBL22313714

SCHEMBL22313714

SCHEMBL22313714

CCc1ccc(-c2cnnc(OC)c2)cc1O

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ GABRG2 P18507 6/20 0.49
▸ GABRB3 P28472 6/20 0.49
▸ GABRA5 P31644 6/20 0.49
▸ GABRA3 P34903 6/20 0.49
▸ GABRA1 P14867 2/20 0.42
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ GAA P10253 1/20 0.40
▸ CYP11B1 P15538 2/20 0.36
▸ CYP11B2 P19099 2/20 0.36
▸ HSD17B1 P14061 2/20 0.35
▸ HSD17B2 P37059 1/20 0.35
▸ ERN1 O75460 2/20 0.34
▸ POLB P06746 2/20 0.33
▸ ESR1 P03372 1/20 0.33
▸ ESR2 Q92731 1/20 0.33
▸ HSP90AA1 P07900 1/20 0.33
▸ HSP90AB1 P08238 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22313787 0.81 SLC13A5 (0.45) —
SCHEMBL22797191 0.80 GABRG2 (0.53) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL23484599 0.79 GABRG2 (0.51) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL22313025 0.78 GABRG2 (0.45) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL16528083 0.77 HSD17B1 (0.50) GABRA1MEN1KMT2AHSD17B1POLB
SCHEMBL22214048 0.77 GABRG2 (0.49) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL22313789 0.72 PDK1 (0.42) MEN1KMT2AGAAESR1ESR2
SCHEMBL29431751 0.72 GABRG2 (0.67) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL22797564 0.71 TNIK (0.47) MEN1KMT2AGAAERN1
SCHEMBL29431764 0.71 GABRG2 (0.45) GABRG2GABRB3GABRA5GABRA3GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230059865-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2023-02-23 — — US disclosed
US-11162101-B2 Methods and compositions for modulating splicing SKYHAWK THERAPEUTICS, INC. (US) 2021-11-02 — — US disclosed
US-11129829-B2 Methods for modulating splicing SKYHAWK THERAPEUTICS, INC. (US) 2021-09-28 — — US disclosed
US-20200390765-A1 METHODS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2020-12-17 — — US disclosed
US-20200247799-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2020-08-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11129829-B2 Methods for modulating splicing RBM17, SNRPE, SNRPB2 GABRG2 1813/4885GABRB3 1127/4885GABRA5 2293/4885
US-20200247799-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING RBM17, SF3B1, SNRPA1 GABRG2 1919/4885GABRB3 1631/4885GABRA5 2677/4885
US-11162101-B2 Methods and compositions for modulating splicing RBM17, SF3B1, SNRPA1 GABRG2 1919/4885GABRB3 1631/4885GABRA5 2677/4885
US-20200390765-A1 METHODS FOR MODULATING SPLICING RBM17, SNRPE, SNRPB2 GABRG2 1813/4885GABRB3 1127/4885GABRA5 2293/4885
US-20230059865-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING RBM17, SF3B1, SNRPA1 GABRG2 1919/4885GABRB3 1631/4885GABRA5 2677/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.