Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22797486 | 1.00 | ALDH1A1 (0.32) | ALDH1A1BACE1CYP3A4MAPK1 | |
| SCHEMBL24673034 | 0.83 | OPRM1 (0.32) | BACE1 | |
| SCHEMBL18379865 | 0.76 | SMYD2 (0.35) | ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL24673821 | 0.74 | BACE1 (0.35) | BACE1CYP3A4 | |
| SCHEMBL25518968 | 0.74 | CYP3A4 (0.36) | ALDH1A1BACE1CYP3A4MAPK1 | |
| SCHEMBL24673828 | 0.73 | ALDH1A1 (0.32) | ALDH1A1CYP3A4 | |
| SCHEMBL24673063 | 0.73 | SMYD2 (0.32) | ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL1139972 | 0.73 | BACE1 (0.36) | BACE1CYP3A4MAPK1 | |
| SCHEMBL17226289 | 0.71 | ALDH1A1 (0.33) | ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL21222671 | 0.71 | BACE1 (0.38) | BACE1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-01 | — | — | US | disclosed |
| WO-2020249663-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | NME2, SLC28A1, SLC28A2 | ALDH1A1 248/4885BACE1 4768/4885CYP3A4 969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.