Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 8/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.51 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.51 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.51 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
| ▸ | GNMT | Q14749 | 2/20 | 0.50 |
| ▸ | P2RX6 | O15547 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.49 |
| ▸ | P2RX5 | Q93086 | 1/20 | 0.49 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30744251 | 0.80 | ADORA3 (0.53) | AHCYHIF1ATMEM97SIGMAR1HSP90B1 | |
| SCHEMBL24673985 | 0.80 | PRMT5 (0.58) | AHCYHIF1ATMEM97SIGMAR1P2RX3 | |
| SCHEMBL24673102 | 0.80 | PRMT5 (0.58) | AHCYHIF1ATMEM97SIGMAR1P2RX3 | |
| SCHEMBL19393175 | 0.79 | P2RX3 (0.54) | AHCYHIF1ATMEM97SIGMAR1P2RX3 | |
| SCHEMBL30861853 | 0.79 | HSP90B1 (0.55) | AHCYHIF1ATMEM97SIGMAR1HSP90B1 | |
| SCHEMBL22707421 | 0.79 | PRMT5 (0.54) | AHCYHIF1ATMEM97SIGMAR1P2RX3 | |
| SCHEMBL22799279 | 0.78 | ADORA3 (0.64) | AHCYHIF1ATMEM97SIGMAR1HSP90B1 | |
| SCHEMBL23982071 | 0.78 | ADORA3 (0.64) | AHCYHIF1ATMEM97SIGMAR1HSP90B1 | |
| SCHEMBL2983119 | 0.78 | ADORA3 (0.64) | AHCYHIF1ATMEM97SIGMAR1HSP90B1 | |
| SCHEMBL22797512 | 0.78 | ADORA3 (0.64) | AHCYHIF1ATMEM97SIGMAR1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-01 | — | — | US | disclosed |
| WO-2020249663-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | NME2, SLC28A1, SLC28A2 | AHCY 998/4885HIF1A 4479/4885TMEM97 3094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.