Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.58 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.58 |
| ▸ | AHCY | P23526 | 6/20 | 0.51 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.51 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.51 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | P2RX6 | O15547 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.49 |
| ▸ | P2RX5 | Q93086 | 1/20 | 0.49 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24673102 | 1.00 | PRMT5 (0.58) | PRMT5WDR77AHCYP2RX3P2RX4 | |
| SCHEMBL22707421 | 0.87 | PRMT5 (0.54) | PRMT5WDR77AHCYP2RX3P2RX4 | |
| SCHEMBL24673581 | 0.81 | PRMT5 (0.80) | PRMT5WDR77AHCYHIF1ATMEM97 | |
| SCHEMBL24673580 | 0.81 | PRMT5 (0.80) | PRMT5WDR77AHCYHIF1ATMEM97 | |
| SCHEMBL24673475 | 0.81 | PRMT5 (0.80) | PRMT5WDR77AHCYHIF1ATMEM97 | |
| SCHEMBL24673136 | 0.81 | PRMT5 (0.80) | PRMT5WDR77AHCYHIF1ATMEM97 | |
| SCHEMBL22799204 | 0.80 | AHCY (0.55) | AHCYP2RX3P2RX4P2RX2ENPP1 | |
| SCHEMBL3365589 | 0.77 | PRMT5 (0.46) | PRMT5WDR77AHCYP2RX3P2RX4 | |
| SCHEMBL13046091 | 0.77 | P2RX3 (0.66) | P2RX3P2RX4P2RX2ENPP1HIF1A | |
| SCHEMBL5797743 | 0.77 | P2RX3 (0.66) | P2RX3P2RX4P2RX2ENPP1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | NME2, SLC28A1, SLC28A2 | PRMT5 3663/4885WDR77 3289/4885AHCY 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.