Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 9/20 | 0.44 |
| ▸ | GALR1 | P47211 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22799838 | 0.77 | ALDH1A1 (0.51) | CAPN1GALR1ALDH1A1MEN1KMT2A | |
| SCHEMBL7966214 | 0.68 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ANR1I2LMNA | |
| SCHEMBL10257995 | 0.68 | MEN1 (0.68) | ALDH1A1MEN1KMT2ANR1I2LMNA | |
| SCHEMBL7849957 | 0.67 | CTSK (0.50) | MEN1KMT2ANR1I2LMNACHRM2 | |
| SCHEMBL12983793 | 0.67 | ALDH1A1 (0.55) | GALR1ALDH1A1MEN1KMT2ANR1I2 | |
| SCHEMBL22800133 | 0.67 | LIG1 (0.46) | CAPN1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7966210 | 0.67 | TSHR (0.63) | ALDH1A1MEN1KMT2ANR1I2LMNA | |
| SCHEMBL11264123 | 0.66 | LMNA (0.54) | ALDH1A1MEN1KMT2ANR1I2LMNA | |
| SCHEMBL24863013 | 0.66 | CAPN1 (0.66) | CAPN1ALDH1A1LMNATP53 | |
| SCHEMBL11331258 | 0.66 | ALDH1A1 (0.78) | ALDH1A1MEN1KMT2ANR1I2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200392157-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | Knobbe, Martens, Olson & Bear, LLP | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392157-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | CAPNS1, CAPN2, CAPN1 | CAPN1 3/4885GALR1 3979/4885ALDH1A1 3918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.