Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SLC37A4 | O43826 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22800285 | 0.94 | ALDH1A1 (0.48) | KDM4CPTPN11KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL22800304 | 0.85 | TSHR (0.43) | KDM4CKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL22800183 | 0.82 | PTPN11 (0.46) | PTPN11KDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL22800284 | 0.81 | SLC6A3 (0.43) | KDM4CPTPN11KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL22799652 | 0.81 | KDM4E (0.44) | KDM4CPTPN11KDM4ESLC37A4SMN1; SMN2 | |
| SCHEMBL22800925 | 0.78 | PTPN11 (0.50) | PTPN11KDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL22800180 | 0.76 | KDM4E (0.44) | KDM4CPTPN11KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL22800245 | 0.72 | KDM4E (0.47) | KDM4EALDH1A1L3MBTL1TDP1 | |
| SCHEMBL850469 | 0.72 | KMT2A (0.65) | KDM4EALDH1A1L3MBTL1KMT2ANPC1 | |
| SCHEMBL3315009 | 0.71 | KDM4E (0.74) | KDM4EALDH1A1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200392157-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | Knobbe, Martens, Olson & Bear, LLP | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392157-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | CAPNS1, CAPN2, CAPN1 | KDM4C 3447/4885PTPN11 4064/4885KDM4E 1957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.