Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22800183 | 0.80 | PTPN11 (0.46) | PTPN11KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL22800302 | 0.78 | KDM4C (0.45) | PTPN11KDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL22800990 | 0.75 | FNTA (0.35) | PTPN11MCL1KDM4EKAT6A | |
| SCHEMBL9186976 | 0.75 | MCL1 (0.44) | MCL1ALDH1A1L3MBTL1 | |
| SCHEMBL11247571 | 0.74 | SMN1; SMN2 (0.51) | PTPN11MCL1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL18763585 | 0.74 | ALDH1A1 (0.53) | PTPN11MCL1ALDH1A1L3MBTL1FFAR1 | |
| SCHEMBL28438658 | 0.74 | PTPN11 (0.60) | PTPN11KDM4EALDH1A1FFAR1KAT6A | |
| SCHEMBL3296021 | 0.73 | ALDH1A1 (0.51) | KDM4EALDH1A1L3MBTL1GAATSHR | |
| SCHEMBL22800285 | 0.72 | ALDH1A1 (0.48) | PTPN11KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3296671 | 0.72 | ALDH1A1 (0.54) | PTPN11MCL1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200392157-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | Knobbe, Martens, Olson & Bear, LLP | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392157-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | CAPNS1, CAPN2, CAPN1 | PTPN11 4064/4885MCL1 2390/4885KDM4E 1957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.