Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALPG | P10696 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598651 | 0.83 | TSHR (0.47) | ALDH1A1LMNASMN1; SMN2HTTHPGD | |
| SCHEMBL7872426 | 0.81 | MME (0.48) | ALDH1A1LMNASMN1; SMN2ALPGHTT | |
| SCHEMBL16563572 | 0.78 | EPHX2 (0.44) | ALDH1A1SMN1; SMN2HPGDTDP1EPHX2 | |
| SCHEMBL20490917 | 0.77 | CES2 (0.43) | ALDH1A1SMN1; SMN2HTTNPC1 | |
| SCHEMBL29582757 | 0.77 | CTSS (0.53) | ALDH1A1LMNASMN1; SMN2ALPGTDP1 | |
| SCHEMBL16563845 | 0.73 | PDE2A (0.47) | EPHX2PDE2A | |
| SCHEMBL23000164 | 0.72 | HTT (0.62) | ALDH1A1LMNAHTTPDE2AKDM4E | |
| SCHEMBL4451432 | 0.72 | HTT (0.62) | ALDH1A1LMNAHTTPDE2AKDM4E | |
| SCHEMBL6174378 | 0.72 | HTT (0.62) | ALDH1A1LMNAHTTPDE2AKDM4E | |
| SCHEMBL10978426 | 0.72 | LMNA (0.53) | ALDH1A1LMNASMN1; SMN2ALPGHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986568-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS AS INHIBITORS OFBCDIN3D ACTIVITY | Storm Therapeutics Ltd (GB) | 2022-04-27 | — | — | EP | disclosed |
| WO-2020254831-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS AS INHIBITORS OFBCDIN3D ACTIVITY | STORM THERAPEUTICS LTD (GB) | 2020-12-24 | — | — | WO | disclosed |